Kids Kidney Research

Abnormal fluid filled cysts destroy normal kidney structure in polycystic kidney disease (PKD), leading to kidney failure in both children and adults. New therapies have been developed for PKD, ranging from very simple ones such as greatly increasing fluid intake through to new drug treatments. Some of these may be impractical or too toxic for young children. An alternative strategy could be to target blood vessels which provide ‘general support’ for cyst growth. This study will examine the role of factors which control blood vessel formation and function in PKD and may identify important new treatments for PKD in children.