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Kids Kidney Research

Kids Kidney Research

Recent projects

Recent grants provided by Kids Kidney Research

All applications made to Kids Kidney Research must first comply with our Research Strategy.  The potential applicant is requested to provide information sufficient for our reviewers.  They will look critically in a number of areas:

  • validity of the research
  • methodology
  • efficiency of resources used.
The applicant will need to comply with our terms and conditions and the application may be scrutinised by the ethics committee of the organisation concerned.  IPR (Intellectual Property Rights) is also considered, in case there is a commercial side to the research - rare in the type of research we usually fund.

Applications for Grants must be received by Kids Kidney Research between 1st September and 31st December in any given year. Applications at other times will not be considered unless by prior agreement.

Kids Kidney Research will provide a decision on each application by 30th June of the following year, with drawdown of the grant scheduled for September of the same year.

Here you will see some of the successful grants.  The physical giving of the money for research is linked directly to the interim reports we receive once a project is underway.
 
Functional characterization of Wnt signalling defects in mouse models of human ciliopathies
Cystic kidney disease comprises a group of inherited conditions, also known as ciliopathies...  More>>
 
Proteomic analyses of kidney glomerular extracellular matrix in health and disease
The kidney has many specialised cells ...  More>>
 
The role of vascular endothelial growth factors (VEGF) and angiopoietins (Ang) in endothelial dysfunction in children with chronic kidney disease (CKD) stage 5
Drug treatment and kidney dialysis is now so successful...  More>>
 
Genetics of renal disease
The majority of kidney disorders in childhood are present from birth...  More>>
 
Evolution of mineral and bone disorder in early CKD: the role of FGF23 and vitamin D
Vitamin D deficiency is common in children with chronic kidney disease (CKD) and begins early in its course.  More>>
 
Human amniotic fluid cells - novel potential renal progenitors.
Amniotic fluid cells - a new way of generating kidneys?  More>>
 
Can renal functional measurements based on Magnetic Resonance Imaging (MRI) detect renal damage following kidney transplantation in children?
Kidney transplantation is the best form of kidney replacement therapy for children with end stage kidney failure.  More>>
 
National study of membranoproliferative glomerulonephritis
Membranoproliferative glomerulonephritis (MPGN) is the term given to a group of rare, progressive kidney disorders.  More>>
 
Autoantibodies to complement regulators and activators in atypical hus.
The pivotal role of the complement system in atypical HUS (aHUS) has recently been recognised.  More>>
 
Defining kidney expression of Teashirt genes in health, injury and regeneration.
Many kidney diseases, of different primary causes, cause cells inside of the kidney to form scar tissue...  More>>
 
An Investigation Into The Optimal Reduction In Dialysate Temperature On Systemic Haemodynamics And Myocardial Stunning In Paediatric Haemodialysis
Patients on dialysis have a very high risk of developing heart and vessel (cardiovascular) disease. In 20-30 yr olds, the chance of dying from cardiovascular disease is the same as that of an 85yr old.  More>>
 
Clinical and molecular aspects of Nephrotic Syndrome.
Nephrotic syndrome is one of the most common kidney diseases in childhood...  More>>
 
Nephronophthisis: molecular mechanisms, disease models and therapy
Recently, kidney researchers have identified several genes, which if mutated, lead to cystic kidneys...  More>>
 
Parents as home based carers
Teaching parents to become home-based care givers of children's long term kidney conditions  More>>
 
The role of the podocyte in the pathogenesis of diarrhoea associated Haemolytic Uraemic Syndrome.
Haemolytic Uraemic Syndrome is the leading reason why children's kidneys fail and require kidney dialysis...  More>>
 
UPDATE MAY 2011 PhD studentship
PhD studentship: Targeting blood vessels to prevent autosomal recessive polycystic kidney disease.  More>>
 
Comprehensive genetic screening of patients with renal malformations:
Kidney failure is a devastating disease in childhood, with reduced life-expectancy and quality of life. About half of these children were born with kidneys which have not formed properly before birth.  More>>
 
Kids Kidney Research fund new project at ICH via BAPN.
Cardiovascular disease reduces life expectancy by 40-60 years in children on dialysis. An important cause is derangement of the hormones PTH and vitamin D...  More>>
 
Kids Kidney Research fund new project at Bristol University via BAPN...
Kidney disease in childhood is very rare, making it difficult to study. Disease registers are essential to get clinical ...  More>>
 
UPDATE MAY 2011 Identification of an X-linked gene conferring susceptibility to membranous nephropathy
Inflammation of the kidneys usually leads to a kidney biopsy to define the severity and nature of the inflammation. One possible diagnosis on the biopsy is membranous nephropathy (MN).  More>>
 
Developing unique human renal progenitor cell lines -- towards novel therapies for congenital and acquired kidney diseases?
Development of the kidney involves interactions between only two cells types that differentiate into nearly all of the different tissues in the adult kidney.  More>>
 
A mechanistic link between plasma factors and podocyte dysfunction in Focal Segmental Glomerulosclerosis
Nephrotic syndrome is a disease of kidney filtration, whereby huge amounts of protein are lost in the urine due to a defect in the primary filtering cell of the kidney, the podocyte.  More>>
 
Does the Heart Behave Abnormally in Children on Dialysis?
Patients on dialysis have a very high risk of developing disease of the heart and blood vessels (cardiovascular disease).  More>>
 
Why do individuals with DiGeorge Syndrome often have kidney malformations?
DiGeorge Syndrome presents with heart defects, palatal anomalies, low blood calcium.......  More>>
 
Understanding how the urinary bladder grows before birth.
Vascular endothelial growth factor is a remarkable growth stimulus to the fetal bladder. How does this molecule stimulate bladder growth and is it implicated in congenital bladder disease?  More>>
 
UPDATE MAY 2011 Finding out what causes childhood renal artery stenosis
High blood pressure in children is usually the result of defined disorders of the kidney and hormonal systems. Renal artery stenosis (RAS)...  More>>
 
Improved prognostic indicators for antenatal urinary tract obstruction
Helping parents when their unborn child is diagnosed with a bladder or kidney blockage...  More>>
 
Understanding why blockage of fetal urine flow causes severe urinary tract disease
Understanding why blockage of fetal urine flow causes severe urinary tract disease  More>>
 
Innate immunity and inflammation in the kidneys
Systemic lupus erythematosus (SLE) is a disease with inflammation that affects different organs in children and adults, which is treated by suppressing the immune system and whose cause is unclear.  More>>
 
Galectin-3 - a novel potential therapy for polycystic kidney disease?
Galectin-3 is a naturally occurring protein involved in several cellular processes, including cell division and death, and the way cells stick to each other. Increased galectin-3 levels....  More>>
 
Long-term tapering versus standard prednisolone (steroid) therapy for the treatment of the initial episode of childhood nephrotic syndrome: national multicentre randomised double blind pilot study
This project is funded jointly by Kids Kidney Research and the National Kidney Research Fund  More>>
 
An investigation into the presence and extent of early markers of vascular calcification in children with chronic renal failure and the role of hyperparathyroidism in these abnormalities
Young people with chronic renal failure (CRF) have a 700-fold increased risk of dying from cardiovascular disease than the general population.  More>>
 
Angiopoietin as a therapy for renal disease
 More>>
 
Genetics of malformations of the human kidney and lower urinary tract
Kidney and renal tract malformations can affect more than one member of a family, making a genetic basis likely.  More>>
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Formerly known as The Kidney Research Aid Fund
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